Follow the Science, Then Keep Going.

For more than a decade, we’ve asked questions, tested what we make, studied the science, and kept looking for better answers. Today, proprietary technology, a portfolio of cannabinoid patents, and a leading body of peer-reviewed research are at the core of what we do. From the genetics of the plant to what’s inside every bottle, every detail matters, because trust is earned through the work behind it.

Proprietary geneticsThird-party testedUSA Grown Hemp

2:24 · Music only, no narration · Transcript with on-screen descriptions

From seed to shipment

“We have traceability from the minute the seed goes into the ground until the package goes out of the warehouse for shipping.”

Dr. Marcel Bonn-Miller, Chief Scientific Officer

Quality standards

We don’t follow industry standards. We define them.

Select a step to see what happens, what we test, and how we hold the line on quality.

Step 01 · Genetics

Where it all begins

Our proprietary hemp genetics have been developed over more than a decade and remain the foundation of our full-spectrum extracts.

What happens

  • Clone production in our greenhouse
  • Every plant is tagged, so it can be traced
  • Planting in the field

How we hold the line

  • Genetics developed by Charlotte’s Web since 2011, and proprietary to us

The highest quality standards in the industry

  • Proprietary hemp genetics
  • USA Grown Hemp
  • Non-GMO
  • Tested by accredited third-party labs
  • cGMP compliant
  • Certificate of Analysis for every batch

Our certifications

  • USDA Organic*Certified organic
  • NSF GMP CertifiedNSF/ANSI 455-2 Dietary Supplements
  • FDA RegisteredMade in our FDA-registered facility
  • ISO/IEC 17025Laboratory accreditation
  • OU KosherKosher certification
  • NASC Quality SealNational Animal Supplement Council

*Select products. See product packaging for details.

Check your batch

See exactly what’s in your bottle.

Enter the lot number printed on your label to see the independent lab results for your batch. Scanning the QR code on your product takes you to our Certificates of Analysis page, where you can look it up too.

Browse all Certificates of Analysis

What every certificate covers

Independent, third-party lab testing
  • Cannabinoid potencyTested
  • PesticidesTested
  • Heavy metalsTested
  • MicrobialsTested
  • Residual solventsTested

The science of cannabinoids

To understand the plant, start with the body.

The endocannabinoid system, or ECS, is a signaling system found throughout the body. It plays a role in regulating processes including sleep, mood, pain, immune function, and stress response.

Cannabinoids are compounds found in hemp that can interact with the ECS in different ways. Understanding those interactions, and what they may mean for human health, continues to be an important area of scientific research.

  • CB1 receptors

    Found primarily in the brain and nervous system, with roles in functions including mood, memory, appetite, pain, and movement.

  • CB2 receptors

    Found throughout the body, particularly in cells associated with the immune system, and studied for their role in immune signaling and inflammation.

Illustration of the human body: CB1 receptors, shown in green, cluster in the brain and along the spinal cord; CB2 receptors, shown in lilac, appear throughout the body

Nature is complex. So are we.

Hemp contains many naturally occurring compounds, including cannabinoids, terpenes, and flavonoids. Researchers continue to study how these compounds work individually and together, and what those interactions could mean.

Coming January 2027

Go deeper into the ECS. Our guide to the endocannabinoid system takes a closer look at how it works and what researchers are continuing to learn.

Scientific Advisory Board

Guided by leading minds in cannabinoid science.

Our research and product decisions are informed by independent physicians and researchers with deep expertise in cannabinoid science.

Marcel Bonn-Miller, Ph.D.

Marcel Bonn-Miller, Ph.D.

Chief Scientific Officer, Charlotte’s Web · Chair, Scientific Advisory Board

Dr. Marcel Bonn-Miller earned a BA in psychology and PhD in clinical psychology from the University of Vermont and completed his Postdoctoral Fellowship at Stanford University School of Medicine. He began his career at the Department of Veterans Affairs and the Department of Psychiatry at the University of Pennsylvania, where he built and directed two fully grant-funded cannabis research centers. He then transitioned to industry roles as Director of Cannabinoid Research at Zynerba Pharmaceuticals, Vice President of Human and Animal Research at Canopy Growth Corporation, and currently serves as Chief Scientific Officer at Charlotte’s Web.

Widely considered one of the early and leading research pioneers in the field of cannabis and mental health, Dr. Bonn-Miller has conducted seminal work on the interrelations between cannabis/cannabinoids and a range of health conditions, including pain, anxiety, HIV, PTSD, and sleep disorders. He brings a unique perspective to cannabinoid therapeutics, having worked in medical center and academic settings for over a decade and within industry for the past 9 years. He serves on the editorial boards of several scientific journals and has published over 175 peer-reviewed empirical publications on cannabis.

More from our Scientific Advisory Board

  • Donald I. Abrams, M.D.

    Donald I. Abrams, M.D.

    Professor Emeritus of Medicine, UCSF

    Dr. Abrams has an integrative oncology practice at the UCSF Osher Center for Integrative Medicine. One of the original clinician-investigators to define early AIDS-related conditions, he was chief of Hematology-Oncology at San Francisco General Hospital for 14 years. He has led clinical trials of medicinal cannabis in HIV, chronic pain and sickle cell disease, and served on the National Academies committee behind The Health Effects of Cannabis and Cannabinoids (2017).
  • Angela D. Bryan, Ph.D.

    Angela D. Bryan, Ph.D.

    Professor of Psychology and Neuroscience, University of Colorado Boulder

    Dr. Bryan is Associate Chair for Faculty Development and co-directs the CU Center for Health and Neuroscience, Genes, and Environment. Her recent work focuses on the public health implications of cannabis legalization, including its effects on metabolism and exercise and its medical use for sleep, pain and anxiety in aging and cancer. Her NIH-funded research spans more than two decades and over 270 peer-reviewed publications.
  • Donna Gutterman, Pharm.D.

    Donna Gutterman, Pharm.D.

    Senior Medical and Marketing Executive

    Dr. Gutterman brings more than 35 years of experience developing, launching and commercializing well-known medicines in depression, urology, antivirals, migraine, allergy and osteoporosis. A results-oriented leader, she has built strong teams across clinical development, global product strategy, commercialization and business development, with specialties in global portfolio management, new product launches, and medical and marketing strategy.
  • Philippe Lucas, Ph.D.

    Philippe Lucas, Ph.D.

    Director, Research & Safe Access, MAPS

    A cannabis and psychedelic researcher and lifelong safe-access advocate, Dr. Lucas founded the Vancouver Island Compassion Society, one of Canada’s first medical cannabis dispensaries, in 1999, and later oversaw an international cannabis research program as VP, Global Patient Research & Access at Tilray. He teaches at the University of Victoria, is a Research Affiliate at the University of Michigan’s Psychedelic Center, and has worked with governments around the globe on evidence-based drug policy.
  • Laszlo Mechtler, M.D.

    Laszlo Mechtler, M.D.

    Chief Medical Officer, Dent Neurologic Institute

    Dr. Mechtler is Professor of Neurology, Oncology and Neurosurgery at the State University of New York at Buffalo and Chief of Neuro-Oncology at Roswell Park Cancer Center. At Dent, the largest outpatient neuroscience center in the United States, he directs the Headache, Cannabis and Neuro-Oncology centers and leads more than 25 clinical trials. He was one of the first researchers to publish large-scale retrospective studies on medical cannabis use, and founded the MIND Clinic in Budapest.

Dr. Bonn-Miller’s Corner

Have a question about the science?

Ask about cannabinoid research, the ECS, a new study, or what the evidence really says. Dr. Bonn-Miller will answer selected questions here.

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Dr. Bonn-Miller’s first answers are on the way. Ask yours, and it could be one of them.

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Dr. Bonn-Miller’s Corner is for general education and is not medical advice. We can’t answer every submission or respond to personal medical questions; please talk with your healthcare provider about your health.

Research & Discovery

What started with a plant keeps opening new possibilities.

For more than a decade, we’ve studied hemp, cannabinoids, and the science behind them. That work has helped deepen our understanding, inform what we make, and open the door to entirely new areas of research.

What we’ve learned

More than a decade of research.

  • Human Research

    Studies designed to better understand cannabinoids and their potential role in health and wellness.

  • Safety & Tolerability

    Research examining how hemp-derived cannabinoids are used and tolerated.

  • Scientific Collaboration

    Work alongside researchers, universities, and scientific organizations to advance cannabinoid knowledge.

  • Published Research

    Peer-reviewed findings that contribute to the broader body of cannabinoid science.

Gloved hands prepare a sample in an amber lab vial

Where that science is leading

Botanical medicine: From hemp research to clinical-stage medicine.

Charlotte’s Web co-founded DeFloria, a clinical-stage botanical pharmaceutical venture developing AJA001, an investigational botanical drug derived from Charlotte’s Web’s proprietary full-spectrum hemp genetics. DeFloria is advancing AJA001 through Phase 2 clinical trials under the FDA Botanical Drug Pathway for irritability associated with autism spectrum disorder.

Learn More About DeFloria (opens in a new tab)

Better answers start with better questions.

Science is part of what keeps this Circle moving forward. Every study gives us something new to understand, and every answer opens the door to another question. So we’ll keep following the evidence, challenging what we know, and doing the work to discover what comes next.

From all of us at Charlotte’s Web

Thank you for being part of the Circle.

For trusting us. For sharing your stories. For using your voice. And for helping carry Charlotte’s legacy forward. We’re grateful you’re here.